Individualized Dosing and Self-Administration | BERINERT C1 Esterase Inhibitor, Human

INDIVIDUALIZED DOSING

Individualized, weight-based dosing and self-administration

During an HAE attack, patients treating with on-demand therapy need the right dose at the first sign of an attack. With BERINERT, patients can self-administer an appropriate dose when and where they need to.

The 1st and only plasma-derived on-demand HAE therapy with weight-based dosing

BERINERT delivers an individualized amount of C1-INH for every patient.

The recommended dosage is 20 IU per kilogram of body weight with an infusion rate of 4 mL/min
Doses lower than 20 IU/kg body weight should not be administered

Time to onset of symptom relief (hours)¹

BERINERT dosing example

BERINERT is supplied in a single-use vial of 500 IU to be reconstituted with 10 mL sterile water for injection
Administer BERINERT at a dose of 20 International Units (IU) per kg body weight by intravenous injection. Doses lower than 20 IU/ 20 IU/kg body weight should not be administered
Examples below administered at 4 mL per minute

Patient weight	Units	Minutes	# of vials
20 kg/44 lb	400 IU	2 min	0.8 vial
45 kg/99 lb	900 IU	4.5 min	1.8 vials
70 kg/154 lb	1400 IU	7 min	2.8 vials

Quickly calculate the recommended dose for your patient by entering their body weight.

Dosing calculator

SELF-ADMINISTRATION

Preparation and reconstitution

Each BERINERT kit consists of:

One single-dose vial of BERINERT
One 10 mL vial of diluent (Sterile Water for Injection, USP)
One Mix2Vial^® filter transfer set
10 mL silicone-free syringe
IV set and butterfly needle
Alcohol swab

View, download, or watch step-by-step instructions on how to reconstitute and administer BERINERT here, or view the full prescribing information for BERINERT.

Empower your patients to self-administer at the first sign of an HAE attack

The treatment works on demand, so it’s used only when patients have an acute abdominal, facial, or laryngeal attack—not to prevent an attack.

Patients can infuse on their own or with help from a caregiver after receiving proper training from a healthcare professional.

Learning how to self-administer can be crucial in the event of a life-threatening laryngeal HAE attack.

Following self-administration of BERINERT for laryngeal HAE attacks, advise patients to immediately seek medical attention.

Self-administration Guide

Download and keep the Self-administration Guide for when you or your patients need it.
Download PDF

Self-administration video

Watch step-by-step instructions on how to self-administer BERINERT by intravenous infusion.
Watch video

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Reference: 1. Bernstein JA, Machnig T, Keinecke H-O, Whelan GJ, Craig TJ. The effect of weight on the efficacy and safety of C1 esterase inhibitor concentrate for the treatment of acute hereditary angioedema. Clin Ther. 2014;36(4):518-525.